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Issuing time:2022-04-28 10:09




上述论文研究结论显示,3 种不同香型的铁观音均可以抑制APP/PS1小鼠脑内氧化应激水平,改善8月龄APP/PS1小鼠的学习记忆能力和焦虑行为,修复小胶质细胞和星形胶质细胞形态。由此可推测,铁观音提取物对AD小鼠脑内炎症反应有一定改善作用。

阿尔茨海默症(Alzheimer's disease, AD),俗称“ 老年痴呆症”,是一种严重的神经退行性疾病。相关数据表明,全球约有5000万人罹患阿尔兹海默症。随着人类平均寿命增长,阿尔兹海默症的患病率也在不断上升,预计到2050年,阿尔兹海默症患者将增加至1.5亿以上。


Recently, the team of Professor Tu Youying from the Department of Tea Science, College of Agriculture and Biotechnology, Zhejiang University published a paper entitled "The effect of Tieguanyin on the behavior of mice with Alzheimer's disease" in the first issue of "Journal of Zhejiang University" (Agriculture and Life Sciences Edition) in 2022. Effects and Mechanisms" research paper.

The study found that Tieguanyin extract has a certain alleviating or protective effect on Alzheimer's disease mouse models, which provides a new theoretical basis for the efficacy of scientific drinking Tieguanyin extract against Alzheimer's disease.

The study pointed out that after treatment with drugs and Tieguanyin extract, the spontaneous alternation reaction rate of mice in the model group was reduced by 16.0% compared with the normal group, which was statistically significant (P<0.001). After treatment with three kinds of Tieguanyin extracts of Chen-flavor, strong-flavor, and Qing-flavor, the working memory ability of APP/PS1 mice was significantly improved compared with the model group, indicating that Tieguanyin extract has the effect of improving the working memory ability of mice. This is consistent with the conclusion that "active components such as tea polyphenols and caffeine in tea have neuroprotective effects on the brain and can effectively alleviate or reduce the incidence of AD".

The research conclusion of the above paper shows that Tieguanyin with three different flavors can inhibit the level of oxidative stress in the brain of APP/PS1 mice, improve the learning and memory ability and anxiety behavior of 8-month-old APP/PS1 mice, and repair microglia. Cell and astrocyte morphology. It can be speculated that the Tieguanyin extract has a certain improvement effect on the inflammatory response in the brain of AD mice.

Alzheimer's disease (AD), commonly known as "senile dementia", is a serious neurodegenerative disease. Relevant data show that about 50 million people worldwide suffer from Alzheimer's disease. As the average human life expectancy increases, the prevalence of Alzheimer's disease is also rising, and it is estimated that by 2050, the number of Alzheimer's patients will increase to more than 150 million.

The etiology of Alzheimer's disease is complex, and the scientific community has not yet deciphered the specific mechanism of Alzheimer's disease. Tea is believed to have anti-oxidative, neuroprotective, anti-aging effects, and aging, oxidative stress, nerve damage and even neuronal apoptosis caused by various reasons are the key factors in the occurrence of Alzheimer's disease. , the research and utilization of tea components in AD is increasing.

Article classification: 铁观音百科
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